A role for JNK-paxillin signaling in cell migration

被引：90

作者：

Huang, C

Jacobson, K

Schaller, MD

机构：

[1] Univ N Carolina, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Comprehens Ctr Inflammatory Disorders, Chapel Hill, NC 27599 USA

来源：

CELL CYCLE | 2004年 / 3卷 / 01期

关键词：

cell migration; JNK; paxillin; phosphorylation;

D O I：

10.4161/cc.3.1.601

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recently, we and others demonstrated that JNK is essential for cell migration in a number of cell types. We also showed that JNK phosphorylates serine 178 on paxillin, a focal adhesion adaptor, both in vitro and in vivo. Moreover, phosphorylation of Ser 178 on paxillin is essential for cell migration and involved in modulating cell adhesions. A model is proposed to depict the role of JNK-paxillin signaling in cell migration.

引用

收藏

页码：4 / 6

页数：3

相关论文

共 43 条

[1] Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling [J].

Abassi, YA ;

Vuori, K .

EMBO JOURNAL, 2002, 21 (17) :4571-4582

[2] Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts [J].

Angers-Loustau, A ;

Côté, JF ;

Charest, A ;

Dowbenko, D ;

Spencer, S ;

Lasky, LA ;

Tremblay, ML .

JOURNAL OF CELL BIOLOGY, 1999, 144 (05) :1019-1031

[3] The c-Jun N-terminal protein kinase family of mitogen-activated protein kinases (JNK MAPKs) [J].

Barr, RK ;

Bogoyevitch, MA .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2001, 33 (11) :1047-1063

[4] Focal adhesions, contractility, and signaling [J].

Burridge, K ;

ChrzanowskaWodnicka, M .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1996, 12 :463-518

[5] Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress [J].

Buschmann, T ;

Potapova, O ;

Bar-Shira, A ;

Ivanov, VN ;

Fuchs, SY ;

Henderson, S ;

Fried, VA ;

Minamoto, T ;

Alarcon-Vargas, D ;

Pincus, MR ;

Gaarde, WA ;

Holbrook, NJ ;

Shiloh, Y ;

Ronai, Z .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (08) :2743-2754

[6] c-Jun NH2-terminal kinase inhibits targeting of the protein phosphatase calcineurin to NFATc1 [J].

Chow, CW ;

Dong, C ;

Flavell, RA ;

Davis, RJ .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (14) :5227-5234

[7] Rho-stimulated contractility drives the formation of stress fibers and focal adhesions [J].

ChrzanowskaWodnicka, M ;

Burridge, K .

JOURNAL OF CELL BIOLOGY, 1996, 133 (06) :1403-1415

[8]

Cox EA, 1998, MICROSC RES TECHNIQ, V43, P412, DOI 10.1002/(SICI)1097-0029(19981201)43:5<412::AID-JEMT7>3.0.CO

[9]

2-F

[10] JNK1 - A PROTEIN-KINASE STIMULATED BY UV-LIGHT AND HA-RAS THAT BINDS AND PHOSPHORYLATES THE C-JUN ACTIVATION DOMAIN [J].

DERIJARD, B ;

HIBI, M ;

WU, IH ;

BARRETT, T ;

SU, B ;

DENG, TL ;

KARIN, M ;

DAVIS, RJ .

CELL, 1994, 76 (06) :1025-1037

← 1 2 3 4 5 →