Galtonioside A, a novel cytotoxic cholestane glycoside from Galtonia candicans

被引：13

作者：

Kuroda, M

Mimaki, Y

Sashida, Y

Yamori, T

Tsuruo, T

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Tokyo 1920392, Japan

[2] Japanese Fdn Canc Res, Ctr Canc Chemotherapy, Toshima Ku, Tokyo 1708455, Japan

[3] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 02期

关键词：

steroid; glycoside; cytotoxic; cytotoxic compound; structure-activity;

D O I：

10.1016/S0040-4039(99)02058-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel polyoxygenated 5 beta-cholestane diglycoside, named galtonioside A, was isolated from the bulbs of Galtonia candicans by way of a cytotoxicity-guided fractionation procedure against HL-60 leukemia cells. Galtonioside A showed differential cytotoxicity in the Jpn. Fdn. for Cancer Res. 38 cell line assay. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：251 / 255

页数：5

共 5 条

[1] THE RELATIONSHIP BETWEEN PROTON-PROTON NMR COUPLING-CONSTANTS AND SUBSTITUENT ELECTRONEGATIVITIES .1. AN EMPIRICAL GENERALIZATION OF THE KARPLUS EQUATION [J].