Glycopeptide-resistant Enterococcus faecium BM4416 is a VanD-type strain with an impaired D-Alanine:D-Alanine ligase

被引：27

作者：

Perichon, B

Casadewall, B

Reynolds, P

Courvalin, P

机构：

[1] Inst Pasteur, Unite Agents Antibacteriens, F-75724 Paris 15, France

[2] Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 05期

关键词：

D O I：

10.1128/AAC.44.5.1346-1348.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

VanD-type Enterococcus faecium BM4416 was constitutively resistant to vancomycin and to teicoplanin by synthesis of peptidoglycan precursors ending in D-alanyl-D-lactate. Like E. faecium BM4339, the only VanD-type strain described so far, BM4416 produced an impaired D-alanine:D-alanine ligase. Unlike for BM4339, which had a 5-bp insertion in ddl, inactivation of the gene in BM4116 was due to insertion of IS19.

引用

页码：1346 / 1348

页数：3

共 15 条

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