Interference between Streptococcus pneumoniae and Staphylococcus aureus:: In vitro hydrogen peroxide-mediated killing by Streptococcus pneumoniae

被引：149

作者：

Regev-Yochay, Gili

Trzcinski, Krzysztof

Thompson, Claudette M.

Malley, Richard

Lipsitch, Marc

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

[3] Childrens Hosp, Dept Med, Div Infect Dis, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Boston, MA 02115 USA

来源：

JOURNAL OF BACTERIOLOGY | 2006年 / 188卷 / 13期

关键词：

D O I：

10.1128/JB.00317-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The bactericidal activity of Streptococcus pneumoniae toward Staphylococcus aureus is mediated by hydrogen peroxide. Catalase eliminated this activity. Pneumococci grown anaerobically or genetically lacking pyruvate oxidase (SpxB) were not bactericidal, nor were nonpneumococcal streptococci. These results provide a possible mechanistic explanation for the interspecies interference observed in epidemiologic studies.

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页码：4996 / 5001

页数：6

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