Alternative splicing: New insights from global analyses

被引：1099

作者：

Blencowe, Benjamin J.

机构：

[1] Univ Toronto, Banting & Best Dept Med Res, Toronto, ON M5S 3E1, Canada

[2] Univ Toronto, Dept Mol & Med Genet, Ctr Cellular & Biomol Res, Toronto, ON M5S 3E1, Canada

来源：

CELL | 2006年 / 126卷 / 01期

基金：

加拿大创新基金会; 加拿大健康研究院;

关键词：

D O I：

10.1016/j.cell.2006.06.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Recent analyses of sequence and microarray data have suggested that alternative splicing plays a major role in the generation of proteomic and functional diversity in metazoan organisms. Efforts are now being directed at establishing the full repertoire of functionally relevant transcript variants generated by alternative splicing, the specific roles of such variants in normal and disease physiology, and how alternative splicing is coordinated on a global level to achieve cell- and tissue-specific functions. Recent progress in these areas is summarized in this review.

引用

收藏

页码：37 / 47

页数：11

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