We examined dendritic protein synthesis after a prolonged blockade of action potentials alone and after a blockade of both action potentials and miniature excitatory synaptic events ( minis). Relative to controls, dendrites exposed to a prolonged blockade of action potentials showed diminished protein synthesis. Dendrites in which both action potentials and minis were blocked showed enhanced protein synthesis, suggesting that minis inhibit dendritic translation. When minis were acutely blocked or stimulated, an immediate increase or decrease, respectively, in dendritic translation was observed. Taken together, these results reveal a role for miniature synaptic events in the acute regulation of dendritic protein synthesis in neurons.
机构:Columbia Univ Coll Phys & Surg, Howard Hughes Med Inst, New York, NY 10032 USA
Casadio, A
;
Martin, KC
论文数: 0引用数: 0
h-index: 0
机构:Columbia Univ Coll Phys & Surg, Howard Hughes Med Inst, New York, NY 10032 USA
Martin, KC
;
Giustetto, M
论文数: 0引用数: 0
h-index: 0
机构:Columbia Univ Coll Phys & Surg, Howard Hughes Med Inst, New York, NY 10032 USA
Giustetto, M
;
Zhu, HX
论文数: 0引用数: 0
h-index: 0
机构:Columbia Univ Coll Phys & Surg, Howard Hughes Med Inst, New York, NY 10032 USA
Zhu, HX
;
Chen, M
论文数: 0引用数: 0
h-index: 0
机构:Columbia Univ Coll Phys & Surg, Howard Hughes Med Inst, New York, NY 10032 USA
Chen, M
;
Bartsch, D
论文数: 0引用数: 0
h-index: 0
机构:Columbia Univ Coll Phys & Surg, Howard Hughes Med Inst, New York, NY 10032 USA
Bartsch, D
;
Bailey, CH
论文数: 0引用数: 0
h-index: 0
机构:Columbia Univ Coll Phys & Surg, Howard Hughes Med Inst, New York, NY 10032 USA
Bailey, CH
;
Kandel, ER
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ Coll Phys & Surg, Howard Hughes Med Inst, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, Howard Hughes Med Inst, New York, NY 10032 USA
机构:
Univ Calif Berkeley, Howard Hughes Med Inst, Dept Mol & Cell Biol, Div Neurobiol, Berkeley, CA 94720 USAUniv Calif Berkeley, Howard Hughes Med Inst, Dept Mol & Cell Biol, Div Neurobiol, Berkeley, CA 94720 USA
Davis, GW
;
Goodman, CS
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Berkeley, Howard Hughes Med Inst, Dept Mol & Cell Biol, Div Neurobiol, Berkeley, CA 94720 USAUniv Calif Berkeley, Howard Hughes Med Inst, Dept Mol & Cell Biol, Div Neurobiol, Berkeley, CA 94720 USA
机构:Columbia Univ Coll Phys & Surg, Howard Hughes Med Inst, New York, NY 10032 USA
Casadio, A
;
Martin, KC
论文数: 0引用数: 0
h-index: 0
机构:Columbia Univ Coll Phys & Surg, Howard Hughes Med Inst, New York, NY 10032 USA
Martin, KC
;
Giustetto, M
论文数: 0引用数: 0
h-index: 0
机构:Columbia Univ Coll Phys & Surg, Howard Hughes Med Inst, New York, NY 10032 USA
Giustetto, M
;
Zhu, HX
论文数: 0引用数: 0
h-index: 0
机构:Columbia Univ Coll Phys & Surg, Howard Hughes Med Inst, New York, NY 10032 USA
Zhu, HX
;
Chen, M
论文数: 0引用数: 0
h-index: 0
机构:Columbia Univ Coll Phys & Surg, Howard Hughes Med Inst, New York, NY 10032 USA
Chen, M
;
Bartsch, D
论文数: 0引用数: 0
h-index: 0
机构:Columbia Univ Coll Phys & Surg, Howard Hughes Med Inst, New York, NY 10032 USA
Bartsch, D
;
Bailey, CH
论文数: 0引用数: 0
h-index: 0
机构:Columbia Univ Coll Phys & Surg, Howard Hughes Med Inst, New York, NY 10032 USA
Bailey, CH
;
Kandel, ER
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ Coll Phys & Surg, Howard Hughes Med Inst, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, Howard Hughes Med Inst, New York, NY 10032 USA
机构:
Univ Calif Berkeley, Howard Hughes Med Inst, Dept Mol & Cell Biol, Div Neurobiol, Berkeley, CA 94720 USAUniv Calif Berkeley, Howard Hughes Med Inst, Dept Mol & Cell Biol, Div Neurobiol, Berkeley, CA 94720 USA
Davis, GW
;
Goodman, CS
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Berkeley, Howard Hughes Med Inst, Dept Mol & Cell Biol, Div Neurobiol, Berkeley, CA 94720 USAUniv Calif Berkeley, Howard Hughes Med Inst, Dept Mol & Cell Biol, Div Neurobiol, Berkeley, CA 94720 USA