The activation of B-Raf and Raf-1 after electroconvulsive shock in the rat hippocampus

被引：9

作者：

Kang, UG

Jeon, SH

Lee, JE

Joo, YH

Yi, JS

Park, JB

Juhnn, YS

Kim, YS ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Med, Dept Psychiat, Seoul, South Korea

[2] Seoul Natl Univ, Coll Med, Dept Biochem, Seoul, South Korea

[3] Sungkyunkwan Univ, Sch Med, Dept Biochem & Mol Biol, Suwon, South Korea

来源：

NEUROPHARMACOLOGY | 2000年 / 39卷 / 04期

关键词：

B-Raf; Raf-1; electroconvulsive shock; hippocampus; MAPK;

D O I：

10.1016/S0028-3908(99)00184-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We demonstrated that ECS activates the kinase activity of B-Raf and Raf-l in the rat hippocampus. The activity was maximal at one minute after ECS and temporally coincided with the increased membrane translocation of Rafs and the reported activity of MAPK, but not with the phosphorylation of Rafs. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：703 / 706

页数：4

共 10 条

[1] Bhat RV, 1998, J NEUROCHEM, V70, P558
[2] Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors - Convergence of G(i)- and G(q)-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase
DellaRocca, GJ
vanBiesen, T
Daaka, Y
Luttrell, DK
Luttrell, LM
Lefkowitz, RJ
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (31) : 19125 - 19132
[3] Jeon SH, 1997, NEUROPHARMACOLOGY, V36, P411
[4] KANG UG, 1994, J NEUROCHEM, V63, P1979
[5] PROTEIN KINASE-C-ALPHA ACTIVATES RAF-1 BY DIRECT PHOSPHORYLATION
KOLCH, W
HEIDECKER, G
KOCHS, G
HUMMEL, R
VAHIDI, H
MISCHAK, H
FINKENZELLER, G
MARME, D
RAPP, UR
[J]. NATURE, 1993, 364 (6434) : 249 - 252
[6] REQUIREMENT FOR RAS IN RAF ACTIVATION IS OVERCOME BY TARGETING RAF TO THE PLASMA-MEMBRANE
LEEVERS, SJ
PATERSON, HF
MARSHALL, CJ
[J]. NATURE, 1994, 369 (6479) : 411 - 414
[7] Modulation of kinase activity and oncogenic properties by alternative splicing reveals a novel regulatory mechanism for B-Raf
Papin, C
Denouel-Galy, A
Laugier, D
Calothy, G
Eychène, A
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (38) : 24939 - 24947
[8] A DIRECT INTERACTION BETWEEN G-PROTEIN BETA-GAMMA-SUBUNITS AND THE, RAF-1 PROTEIN-KINASE
PUMIGLIA, KM
LEVINE, H
HASKE, T
HABIB, T
JOVE, R
DECKER, SJ
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (24) : 14251 - 14254
[9] STORM SM, 1990, ONCOGENE, V5, P345
[10] cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway
Vossler, MR
Yao, H
York, RD
Pan, MG
Rim, CS
Stork, PJS
[J]. CELL, 1997, 89 (01) : 73 - 82

← 1 →