Erythropoietin as an antiapoptotic, tissue-protective cytokine

被引：257

作者：

Ghezzi, P

Brines, M

机构：

[1] Mario Negri Inst Pharmacol Res, Lab Neuroimmunol, I-20157 Milan, Italy

[2] Kenneth Warren Inst, Ossining, NY USA

来源：

CELL DEATH AND DIFFERENTIATION | 2004年 / 11卷 / Suppl 1期

关键词：

erythropoietin; neuron; neurodegeneration;

D O I：

10.1038/sj.cdd.4401450

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Erythropoietin (EPO) increases the number of circulating erythrocytes primarily by preventing apoptosis of erythroid progenitors. In addition to this proerythroid action, results of recent studies show that systemically administered EPO is protective in vivo, in several animal models of neuronal injury. In vitro, EPO prevents neuronal apoptosis induced by a variety of stimuli. This review summarizes the neuroprotective actions of EPO and discusses the underlying mechanisms in terms of signal transduction pathways involved. The understanding of these mechanisms will help differentiate the neuroprotective actions of EPO from its role in the bone marrow.

引用

收藏

页码：S37 / S44

页数：8

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