Variable benefit in neuropsychological function in HIV-infected HAART-treated patients

被引：115

作者：

Cysique, LAJ

Maruff, P

Brew, BJ

机构：

[1] Univ New S Wales, St Vincents Clin Sch, Fac Med, Sydney, NSW, Australia

[2] La Trobe Univ, Sch Psychol, Melbourne, Vic, Australia

[3] St Vincents Hosp, Dept Neurol, Sydney, NSW 2010, Australia

[4] St Vincents Hosp, Dept HIV Med, Sydney, NSW 2010, Australia

来源：

NEUROLOGY | 2006年 / 66卷 / 09期

关键词：

D O I：

10.1212/01.wnl.0000210477.63851.d3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors examined cognitive performance change in 101 individuals with advanced HIV infection on highly active antiretroviral therapy ( HAART), using standard neuropsychological testing in three visits, over a 27-month-period. Cognitive performance stabilized in a majority of HIV + participants over time. A neuroactive HAART regimen was associated with neuropsychological improvement. Decline occurred in a minority with lower nadir CD4. The current CD4 count and plasma viral load were not associated with cognitive change.

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收藏

页码：1447 / 1450

页数：4

相关论文

共 10 条

[1] STATISTICS NOTES .12. CALCULATING CORRELATION-COEFFICIENTS WITH REPEATED OBSERVATIONS .1. CORRELATION WITHIN-SUBJECTS [J].

BLAND, JM ;

ALTMAN, DG .

BRITISH MEDICAL JOURNAL, 1995, 310 (6977) :446-446

[2] Prevalence and pattern of neuropsychological impairment in human immunodeficiency virus-infected/acquired immunodeficiency syndrome (HIV/AIDS) patients across pre- and post-highly active antiretroviral therapy eras: A combined study of two cohorts [J].

Cysique, LA ;

Maruff, P ;

Brew, BJ .

JOURNAL OF NEUROVIROLOGY, 2004, 10 (06) :350-357

[3] Antiretroviral therapy in HIV infection - Are neurologically active drugs important? [J].

Cysique, LAJ ;

Maruff, P ;

Brew, BJ .

ARCHIVES OF NEUROLOGY, 2004, 61 (11) :1699-1704

[4] Marked improvement in survival following AIDS dementia complex in the era of highly active antiretroviral therapy [J].

Dore, GJ ;

McDonald, A ;

Li, YM ;

Kaldor, JM ;

Brew, BJ .

AIDS, 2003, 17 (10) :1539-1545

[5] HIV-1 infection and AIDS dementia are influenced by a mutant MCP-1 allele linked to increased monocyte infiltration of tissues and MCP-1 levels [J].

Gonzalez, E ;

Rovin, BH ;

Sen, L ;

Cooke, G ;

Dhanda, R ;

Mummidi, S ;

Kulkarni, H ;

Bamshad, MJ ;

Telles, V ;

Anderson, SA ;

Walter, EA ;

Stephan, KT ;

Deucher, M ;

Mangano, A ;

Bologna, R ;

Ahuja, SS ;

Dolan, MJ ;

Ahuja, SK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (21) :13795-13800

[6] An empirical approach to determining criteria for abnormality in test batteries with multiple measures [J].

Ingraham, LJ ;

Aiken, CB .

NEUROPSYCHOLOGY, 1996, 10 (01) :120-124

[7] Development of a statistical approach to classifying treatment response in individual children with ADHD [J].

Mollica, CM ;

Maruff, P ;

Vance, A .

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL, 2004, 19 (07) :445-456

[8] Practice and drop-out effects during a 17-year longitudinal study of cognitive aging [J].

Rabbitt, P ;

Diggle, P ;

Holland, F ;

McInnes, L .

JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES, 2004, 59 (02) :P84-P97

[9] HIV-associated cognitive impairment before and after the advent of combination therapy [J].

Sacktor, N ;

McDermott, MP ;

Marder, K ;

Schifitto, G ;

Selnes, OA ;

McArthur, JC ;

Stern, Y ;

Albert, S ;

Palumbo, D ;

Kieburtz, K ;

De Marcaida, JA ;

Cohen, B ;

Epstein, L .

JOURNAL OF NEUROVIROLOGY, 2002, 8 (02) :136-142

[10]

Tozzi V, 2001, J ACQ IMMUN DEF SYND, V28, P19, DOI 10.1097/00042560-200109010-00004