Interference of antibody production to hepatitis B surface antigen in a combination hepatitis A/hepatitis B vaccine

被引:32
作者
Frey, S
Dagan, R
Ashur, Y
Chen, XQ
Ibarra, J
Kollaritsch, H
Mazur, MH
Poland, GA
Reisinger, K
Waiter, E
Van Damme, P
Braconier, JH
Uhnoo, I
Wahl, M
Blatter, MM
Clements, D
Greenberg, D
Jacobson, RM
Norrby, SR
Rowe, M
Shouval, D
Simmons, SS
van Hattum, J
Wennerholm, S
Gress, JO
Chan, I
Kuter, B
机构
[1] St Louis Univ, Hlth Sci Ctr, Div Infect Dis & Immunol, St Louis, MO 63110 USA
[2] Soroka Univ, Med Ctr, Pediat Infect Dis Unit, Beer Sheva, Israel
[3] Ben Gurion Univ Negev, IL-84105 Beer Sheva, Israel
[4] Hadassah Univ Hosp, Dept Internal Med, Liver Unit, IL-91120 Jerusalem, Israel
[5] Univ Utrecht Hosp, Dept Gastroenterol, Utrecht, Netherlands
[6] Future HealthCare, Fresno, CA USA
[7] Robles Reg Med Ctr, Thousand Oaks, CA USA
[8] Univ Vienna, Inst Specif Prophylaxis & Trop Med, Vienna, Austria
[9] Mayo Clin & Mayo Fdn, Dept Med, Dept Pediat & Adolescent Med, Rochester, MN 55905 USA
[10] Primary Phys Res, Pittsburgh, PA USA
[11] Merck & Co Inc, Blue Bell, PA USA
[12] Duke Univ, Med Ctr, Dept Pediat, Duke Vaccine Unit, Durham, NC 27710 USA
[13] Univ Antwerp, Dept Epidemiol & Community Med, B-2020 Antwerp, Belgium
[14] Univ Lund, Dept Infect Dis & Med Microbiol, S-22100 Lund, Sweden
[15] Univ Uppsala Hosp, Dept Med Sci, Infect Dis Sect, Uppsala, Sweden
[16] SU Ostra, Dept Infect Dis, Gothenburg, Sweden
关键词
D O I
10.1086/315119
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A randomized trial comparing 3 manufacturing consistency lots of a combination hepatitis A/hepatitis B vaccine to each other and to hepatitis A vaccine and hepatitis B vaccine given separately and concurrently was done to evaluate safety, tolerability, and immunogenicity. Healthy volunteers greater than or equal to 11 years of age were divided into 4 groups. Each of 3 groups received a separate consistency lot of the combination vaccine, and 1 group received separate but concurrent injections of hepatitis A and hepatitis B vaccines. Injections were given at weeks 0 and 24. The combination vaccine was generally well tolerated. The hepatitis A portion of the combination vaccine produced clinically acceptable high seropositivity rates 4 and 52 weeks after the first injection. The hepatitis B portion of the vaccine did not produce clinically acceptable seropositivity rates 4 weeks after the second injection. Lack of antibody production may be attributed, at least in part, to immunologic interference.
引用
收藏
页码:2018 / 2022
页数:5
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