Insights into bactericidal action of surface-attached poly(vinyl-N-hexylpyridinium) chains

被引：130

作者：

Lin, J

Tiller, JC

Lee, SB

Lewis, K

Klibanov, AM ^{[1
]}

机构：

[1] MIT, Dept Chem, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[2] Northeastern Univ, Dept Biol, Boston, MA 02115 USA

来源：

BIOTECHNOLOGY LETTERS | 2002年 / 24卷 / 10期

关键词：

antibacterial; immobilized; polycation; polymer; surfaces;

D O I：

10.1023/A:1015584423358

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The surface of polyethylene slides nanocoated with silica and derivatized with long-chain poly(vinyl-N-hexylpyridinium) becomes permanently bactericidal: it kills 90-99% of (both airborne and waterborne) wild-type and antibiotic-resistant strains of the human pathogen Staphylococcus aureus. The material created was similarly lethal to strains expressing multidrug resistance pumps, the only known mechanism of resistance to cationic antiseptics.

引用

页码：801 / 805

页数：5

共 17 条

[1]

Cunliffe D, 1999, APPL ENVIRON MICROB, V65, P4995

[2] Archaic strains of methicillin-resistant Staphylococcus aureus:: Molecular and microbiological properties of isolates from the 1960s in Denmark [J].