Nuclear receptor regulation of cholesterol and bile acid metabolism

被引：162

作者：

Repa, JJ ^{[1
]}

Mangelsdorf, DJ ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dept Pharmacol, Dallas, TX 75235 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 1999年 / 10卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0958-1669(99)00031-2

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The metabolism of cholesterol and bile acids is transcriptionally regulated by classic feedforward and feedback signaling pathways. The mechanisms underlying this regulation have recently been elucidated by the characterization of three classes of orphan nuclear receptors. Furthermore, the study of these receptors suggests their potential as targets for new drug therapies.

引用

页码：557 / 563

页数：7

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