Multiple pathways control protein kinase C phosphorylation

被引:496
作者
Parekh, DB [1 ]
Ziegler, W [1 ]
Parker, PJ [1 ]
机构
[1] Imperial Canc Res Fund, London WC2A 3PX, England
关键词
mTOR; PDK1; phosphatidylinositol; 3-kinase; PKC-related kinase; protein kinase C;
D O I
10.1093/emboj/19.4.496
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:496 / 503
页数:8
相关论文
共 43 条
[1]   Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha [J].
Alessi, DR ;
James, SR ;
Downes, CP ;
Holmes, AB ;
Gaffney, PRJ ;
Reese, CB ;
Cohen, P .
CURRENT BIOLOGY, 1997, 7 (04) :261-269
[2]   Mechanism of activation of protein kinase B by insulin and IGF-1 [J].
Alessi, DR ;
Andjelkovic, M ;
Caudwell, B ;
Cron, P ;
Morrice, N ;
Cohen, P ;
Hemmings, BA .
EMBO JOURNAL, 1996, 15 (23) :6541-6551
[3]   PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2 [J].
Balendran, A ;
Casamayor, A ;
Deak, M ;
Paterson, A ;
Gaffney, P ;
Currie, R ;
Downes, CP ;
Alessi, DR .
CURRENT BIOLOGY, 1999, 9 (08) :393-404
[4]   Phosphorylation of threonine 638 critically controls the dephosphorylation and inactivation of protein kinase C alpha [J].
Bornancin, F ;
Parker, PJ .
CURRENT BIOLOGY, 1996, 6 (09) :1114-1123
[5]   Phosphorylation of protein kinase C-zeta on serine 657 controls the accumulation of active enzyme and contributes to its phosphatase-resistant state [J].
Bornancin, F ;
Parker, PJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (06) :3544-3549
[6]   CONTINUOUS SYNTHESIS OF 2 PROTEIN-KINASE C-RELATED PROTEINS AFTER DOWN-REGULATION BY PHORBOL ESTERS [J].
BORNER, C ;
EPPENBERGER, U ;
WYSS, R ;
FABBRO, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (07) :2110-2114
[7]   THREONINE-497 IS A CRITICAL SITE FOR PERMISSIVE ACTIVATION OF PROTEIN-KINASE C-ALPHA [J].
CAZAUBON, S ;
BORNANCIN, F ;
PARKER, PJ .
BIOCHEMICAL JOURNAL, 1994, 301 :443-448
[8]   Regulation of protein kinase C ζ by PI 3-kinase and PDK-1 [J].
Chou, MM ;
Hou, WM ;
Johnson, J ;
Graham, LK ;
Lee, MH ;
Chen, CS ;
Newton, AC ;
Schaffhausen, BS ;
Toker, A .
CURRENT BIOLOGY, 1998, 8 (19) :1069-1077
[9]   PROTEIN-KINASE-C - A QUESTION OF SPECIFICITY [J].
DEKKER, LV ;
PARKER, PJ .
TRENDS IN BIOCHEMICAL SCIENCES, 1994, 19 (02) :73-77
[10]   Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1) [J].
Dutil, EM ;
Toker, A ;
Newton, AC .
CURRENT BIOLOGY, 1998, 8 (25) :1366-1375