3-Nitro-3-deaza-2'-deoxyadenosine as a versatile photocleavable 2'-deoxyadenosine mimic

被引：19

作者：

Crey-Desbiolles, C ^{[1
]}

Lhomme, J ^{[1
]}

Dumy, P ^{[1
]}

Kotera, M ^{[1
]}

机构：

[1] Univ Grenoble 1, CNRS, ICMG, UMR 5616,LEDSS,FR 2607, F-38041 Grenoble, France

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 31期

关键词：

D O I：

10.1021/ja047976m

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new photocleavable 2′-deoxyadenosine mimic, 3-nitro-3-deaza-2′-deoxyadenosine (NidA), was prepared and introduced into DNA fragments via its 6-O-trimethylphenyl precursor phophoramidite. Photocleavage of the resulting oligonucleotide is highly efficient in single and double strands. Hybridization properties of NidA are very similar to those of deoxyadenosine. Copyright © 2004 American Chemical Society.

引用

页码：9532 / 9533

页数：2

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