Differential SPR immunosensing

被引：48

作者：

Berger, CEH ^{[1
]}

Greve, J ^{[1
]}

机构：

[1] Univ Twente, Dept Appl Phys, MESA Inst, Appl Opt Grp, NL-7500 AE Enschede, Netherlands

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2000年 / 63卷 / 1-2期

关键词：

immunosensor; surface plasmon resonance;

D O I：

10.1016/S0925-4005(00)00307-5

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

In this work we describe a surface plasmon resonance (SPR) sensor with a differential detection of the SPR angle, and demonstrate it. The angle of incidence is modulated by a simple piezo-electric actuator, and the reflectance signal is measured with a lockin-amplifier. When the conditions for SPR are fulfilled, the differential signal is zero. The shift of the resonance conditions can be measured as an increase of the differential signal, or using feedback on the angle of incidence. The sensor will be demonstrated by monitoring an adsorption and an immunoreaction at the sensor surface with sub-mdeg. resolution. The modulated incident beam can also be scanned past a number of sensing areas, making multichannel measurements possible, as will be demonstrated. (C) 2000 Elsevier Science S.A. All rights reserved.

引用

页码：103 / 108

页数：6

共 29 条

[1]

BRINK G, 1995, SENSOR ACTUAT B-CHEM, V24, P756

[2] THE RESONANT MIRROR - A NOVEL OPTICAL SENSOR FOR DIRECT SENSING OF BIOMOLECULAR INTERACTIONS .2. APPLICATIONS [J].

BUCKLE, PE ;

DAVIES, RJ ;

KINNING, T ;

YEUNG, D ;

EDWARDS, PR ;

POLLARDKNIGHT, D ;

LOWE, CR .

BIOSENSORS & BIOELECTRONICS, 1993, 8 (7-8) :355-363

[3] AN OPTICAL-TEMPERATURE SENSOR USING SURFACE-PLASMONS [J].

CHADWICK, B ;

GAL, M .

JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS, 1993, 32 (6A) :2716-2717

[4] THE RESONANT MIRROR - A NOVEL OPTICAL BIOSENSOR FOR DIRECT SENSING OF BIOMOLECULAR INTERACTIONS .1. PRINCIPLE OF OPERATION AND ASSOCIATED INSTRUMENTATION [J].

CUSH, R ;

CRONIN, JM ;

STEWART, WJ ;

MAULE, CH ;

MOLLOY, J ;

GODDARD, NJ .

BIOSENSORS & BIOELECTRONICS, 1993, 8 (7-8) :347-353

[5] SURFACE-PLASMON RESONANCE APPLIED TO IMMUNOSENSING [J].

DANIELS, PB ;

DEACON, JK ;

EDDOWES, MJ ;

PEDLEY, DG .

SENSORS AND ACTUATORS, 1988, 15 (01) :11-18

[6] DETERMINATION OF DIELECTRIC PERMITTIVITY AND THICKNESS OF A METAL LAYER FROM A SURFACE-PLASMON RESONANCE EXPERIMENT [J].

DEBRUIJN, HE ;

KOOYMAN, RPH ;

GREVE, J .

APPLIED OPTICS, 1990, 29 (13) :1974-1978

[7] A COMPACT OPTOELECTRONIC INSTRUMENT WITH A DISPOSABLE SENSOR-BASED ON SURFACE-PLASMON RESONANCE [J].

DOUGHERTY, G .

MEASUREMENT SCIENCE AND TECHNOLOGY, 1993, 4 (06) :697-699

[8]

GASS PA, 1992, Patent No. 2254693

[9] WAVE-GUIDE SURFACE-PLASMON RESONANCE SENSORS [J].

HARRIS, RD ;

WILKINSON, JS .

SENSORS AND ACTUATORS B-CHEMICAL, 1995, 29 (1-3) :261-267

[10] PERFORMANCE OF A HIGHLY SENSITIVE OPTICAL WAVE-GUIDE MACH-ZEHNDER INTERFEROMETER IMMUNOSENSOR [J].

HEIDEMAN, RG ;

KOOYMAN, RPH ;

GREVE, J .

SENSORS AND ACTUATORS B-CHEMICAL, 1993, 10 (03) :209-217

← 1 2 3 →