Toward a novel metal-based chemotherapy against tropical diseases .3. Synthesis and antimalarial activity in vitro and in vivo of the new gold-chloroquine complex [Au(PPh3)(CQ)]PF6

被引：141

作者：

Navarro, M

Perez, H

SanchezDelgado, RA

机构：

[1] INST VENEZOLANO INVEST CIENT,TRANSIT MET CHEM LAB,CARACAS 1020A,VENEZUELA

[2] INST VENEZOLANO INVEST CIENT,IMMUNOPARASITOL LAB,CARACAS 1020A,VENEZUELA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1997年 / 40卷 / 12期

关键词：

D O I：

10.1021/jm9607358

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Reaction of AuPPh3Cl with chloroquine (CQ) and KPF6 leads to the new complex [Au(PPh3)(CQ)]PF6 (1) which was found to be considerably more active than CQ diphosphate and other previously reported metal-CQ complexes against two chloroquine-resistant strains of Plasmodium falciparum in vitro and also active against Plasmodium berghei in vitro and in vivo.

引用

页码：1937 / 1939

页数：3

共 20 条

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