Effect of estradiol versus estradiol and testosterone on brain-activation patterns in postmenopausal women

被引:57
作者
Archer, Johanna S.
Love-Geffen, Tracy E.
Herbst-Damm, Kathryn L.
Swinney, David A.
Chang, Jeffrey R.
机构
[1] Univ Minnesota, Dept Obstet & Gynecol, Reprod Med Ctr, Minneapolis, MN 55454 USA
[2] San Diego State Univ, Sch Speech Hearing & Language Sci, San Diego, CA 92182 USA
[3] Univ Calif San Diego, Dept Psychol, La Jolla, CA 92093 USA
[4] Univ Calif San Diego, Dept Reprod Med, La Jolla, CA 92093 USA
来源
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY | 2006年 / 13卷 / 03期
关键词
postmenopausal; sexual arousal; estrogen; testosterone; functional magnetic resonance imaging; brain;
D O I
10.1097/01.gme.0000188737.46746.cd
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To determine the effect of estradiol and testosterone on brain-activation patterns in surgically postmenopausal women viewing erotic video clips using functional magnetic resonance imaging. Design: Six women, who had undergone a bilateral oophorectomy and hysterectomy for benign disease, viewed erotic and neutral videos during functional magnetic resonance imaging while not on hormone therapy, while on estradiol therapy, and while on estradiol and testosterone therapy. Five similarly aged premenopausal women viewed the same videos. Areas of brain activation between the functional magnetic resonance imaging scans of both groups of women were compared to determine whether agonadal serum levels of sex hormones and administration of estradiol and testosterone impacted brain patterns of sexual arousal. Results: When compared with premenopausal women, untreated postmenopausal women had significantly decreased areas of brain activation during both erotic and neutral stimulations. Administration of estradiol increased global brain-activation patterns during both visual stimulations, with erotic video viewing causing a limited increase in limbic system activation. Combined estradiol and testosterone therapy was associated with a greater activation of the central nervous system, with more limbic system activated during the erotic video. Brain-activation patterns of the postmenopausal women were similar to the premenopausal group only during the estradiol and testosterone treatment phase. Conclusions: Agonadal serum hormone levels result in globally decreased brain-activation patterns in postmenopausal women while viewing neutral and erotic videos. Administration of both estradiol and testosterone increase global brain activation, and, both sex steroids are independently associated with enhanced limbic system response during erotic visual stimulation.
引用
收藏
页码:528 / 537
页数:10
相关论文
共 28 条
[1]   The impact of hormones on menopausal sexuality: a literature review [J].
Bachmann, GA ;
Leiblum, SR .
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, 2004, 11 (01) :120-130
[2]   Androgen cotherapy in menopause: Evolving benefits and challenges [J].
Bachmann, GA .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1999, 180 (03) :S308-S311
[3]   Bioidentical hormone therapy: a review [J].
Boothby, LA ;
Doering, PL ;
Kipersztok, S .
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, 2004, 11 (03) :356-367
[4]  
Braunstein GD, 2002, FERTIL STERIL, V77, pS94
[5]  
Cox RW, 1997, NMR BIOMED, V10, P171, DOI 10.1002/(SICI)1099-1492(199706/08)10:4/5<171::AID-NBM453>3.0.CO
[6]  
2-L
[7]   Dynamic MR imaging of the female genitalia using AngioMARK: initial experience evaluating the female sexual response [J].
Deliganis, AV ;
Maravilla, KR ;
Heiman, JR ;
Carter, W ;
Weisskoff, RM ;
Garland, P ;
Echelard, D ;
Hackbert, L ;
Schmiedl, UP .
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH, 2000, 12 (Suppl 3) :S45-S45
[8]   IMPROVED ASSESSMENT OF SIGNIFICANT ACTIVATION IN FUNCTIONAL MAGNETIC-RESONANCE-IMAGING (FMRI) - USE OF A CLUSTER-SIZE THRESHOLD [J].
FORMAN, SD ;
COHEN, JD ;
FITZGERALD, M ;
EDDY, WF ;
MINTUN, MA ;
NOLL, DC .
MAGNETIC RESONANCE IN MEDICINE, 1995, 33 (05) :636-647
[9]  
Graziani R, 1998, ART CRITICISM, V13, P5
[10]   Men and women differ in amygdala response to visual sexual stimuli [J].
Hamann, S ;
Herman, RA ;
Nolan, CL ;
Wallen, K .
NATURE NEUROSCIENCE, 2004, 7 (04) :411-416