Silicon nanoparticles produced by femtosecond laser ablation in water as novel contamination-free photosensitizers

被引：75

作者：

Rioux, David ^{[1
]}

Laferriere, Marie ^{[1
]}

Douplik, Alexandre ^{[2
]}

Shah, Duoaud ^{[2
]}

Lilge, Lothar ^{[2
]}

Kabashin, Andrei V. ^{[1
]}

Meunier, Michel M. ^{[1
]}

机构：

[1] Ecole Polytech, Dept Genie Phys, Laser Proc Lab, Montreal, PQ H3C 3A7, Canada

[2] Princess Margaret Hosp, Univ Hlth Network, Ontario Canc Inst, Toronto, ON M5G 2M9, Canada

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2009年 / 14卷 / 02期

关键词：

silicon nanoparticles; photosensitizers; singlet oxygen; phototoxicity; laser ablation; GOLD NANOPARTICLES; PHOTODYNAMIC THERAPY; OXYGEN; INACTIVATION; LUMINESCENCE; NANOCRYSTALS; PORPHYRINS; BLUE;

D O I：

10.1117/1.3086608

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We report the synthesis of novel inorganic contamination-free photosensitizers based on colloidal silicon nanoparticles prepared by laser ablation in pure deionized water. We show that such nanoparticles are capable of generating singlet oxygen (O-1(2)) under laser irradiation with a yield estimated at 10% of that of photofrin, which makes them a potential candidate for therapeutics, antiseptics, or disinfectants. We also discuss a model of 1O2 generation and the possibility for optimizing its release. Potential advantages of such novel inorganic photosensitizers include stable and nonphotobleaching O-1(2) release, easy removal, and low dark toxicity. (C) 2009 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3086608]

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