How cigarette smoke skews immune responses to promote infection, lung disease and cancer

被引：500

作者：

Staempfli, Martin R. ^{[1
,2
]}

Anderson, Gary P. ^{[3
,4
]}

机构：

[1] McMaster Univ, Dept Pathol & Mol Med, Ctr Gene Therapeut, Hamilton, ON, Canada

[2] McMaster Univ, Dept Med, Hamilton, ON, Canada

[3] Univ Melbourne, Dept Med, Parkville, Vic 3010, Australia

[4] Univ Melbourne, Dept Pharmacol, Parkville, Vic 3010, Australia

来源：

NATURE REVIEWS IMMUNOLOGY | 2009年 / 9卷 / 05期

关键词：

OBSTRUCTIVE PULMONARY-DISEASE; ALLERGIC AIRWAY INFLAMMATION; INDUCED DNA-DAMAGE; T-CELL; DENDRITIC CELLS; ALVEOLAR MACROPHAGES; INDUCED EMPHYSEMA; EPITHELIAL PERMEABILITY; CYTOKINE RELEASE; INNATE IMMUNE;

D O I：

10.1038/nri2530

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A complex and multilayered immune defence system protects the host against harmful agents and maintains tissue homeostasis. Cigarette smoke exposure markedly impacts the immune system, compromising the host's ability to mount appropriate immune and inflammatory responses and contributing to smoking-related pathologies. These adverse effects on the immune system not only occur in active smokers, but also in those exposed to smoke passively in contaminated environments, and may persist for decades after exposure has ended.

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收藏

页码：377 / 384

页数：8

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