Zebrafish fgfr1 is a member of the fgf8 synexpression group and is required for fgf8 signalling at the midbrain-hindbrain boundary

被引：52

作者：

Scholpp, S

Groth, C

Lohs, C

Lardelli, M

Brand, M ^{[1
]}

机构：

[1] Dresden Univ Technol, Dept Genet, Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany

[2] Univ Adelaide, Sch Mol & Biomed Sci, Adelaide, SA 5005, Australia

来源：

DEVELOPMENT GENES AND EVOLUTION | 2004年 / 214卷 / 06期

基金：

澳大利亚研究理事会;

关键词：

fibroblast growth factor receptor 1; Fgf8; midbrain-hindbrain boundary; zebrafish; Acerebellar;

D O I：

10.1007/s00427-004-0409-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

FGFR1 is an important signalling molecule during embryogenesis and in adulthood. FGFR1 mutations in human may lead to developmental defects and pathological conditions, including cancer and Alzheimer's disease. Here, we describe cloning and expression analysis of the zebrafish fibroblast growth factor receptor 1 (fgfr1). Initially, fgfr1 is expressed in the adaxial mesoderm with transcripts distinctly localised to the anterior portion of each half-somite. Hereupon, fgfr1 is also strongly expressed in the otic vesicles, branchial arches and the brain, especially at the midbrain-hindbrain boundary (MHB). The expression patterns of fgfr1 and fgf8 are strikingly similar and knock-down of fgfr1 phenocopies many aspects observed in the fgf8 mutant acerebellar, suggesting that Fgf8 exerts its function mainly by binding to FgfR1.

引用

页码：285 / 295

页数：11

共 53 条

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AMAYA E, 1993, DEVELOPMENT, V118, P477

[2]

Brand M, 1996, DEVELOPMENT, V123, P179

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