Effects of baclofen and phaclofen on receptive field properties of rat whisker barrel neurons

被引：34

作者：

Kyriazi, HT ^{[1
]}

Carvell, GE ^{[1
]}

Brumberg, JC ^{[1
]}

Simons, DJ ^{[1
]}

机构：

[1] UNIV PITTSBURGH,SCH HLTH & REHABIL SCI,DEPT PHYS THERAPY,PITTSBURGH,PA 15261

来源：

BRAIN RESEARCH | 1996年 / 712卷 / 02期

关键词：

gamma-aminobutyric acid; somatosensory; cortex; inhibition; microiontophoresis;

D O I：

10.1016/0006-8993(95)01562-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Extracellular single-unit recordings were made in somatosensory cortical barrels of fentanyl-sedated rats. Whiskers were deflected singly or in paired combinations. Iontophoretically-applied (-)-baclofen disproportionately reduced weak responses, and phaclofen disproportionately increased them, resulting in more tightly focused or more broadly focused receptive fields, respectively. Both drugs had only minor effects on surround inhibition. In light of previous findings, we conclude that GABA(A) and GABA(B) mechanisms both act to enhance spatial contrast, but that the former plays a much greater role in enhancing temporal resolution.

引用

页码：325 / 328

页数：4

共 20 条

[1]

ALLOWAY K, 1992, EXP BRAIN RES, V85, P598

[2]

ALLOWAY KD, 1989, EXP BRAIN RES, V78, P514

[3] BICUCULLINE-INDUCED ALTERATIONS IN NEURONAL RESPONSES TO CONTROLLED TACTILE STIMULI IN THE 2ND SOMATOSENSORY CORTEX OF THE CAT - A MICROIONTOPHORETIC STUDY [J].

ALLOWAY, KD ;

BURTON, H .

SOMATOSENSORY RESEARCH, 1986, 3 (03) :197-211

[4]

BATUEV AS, 1989, EXP BRAIN RES, V76, P198

[5] PICROTOXIN ACTION ON THE RECEPTIVE-FIELDS OF THE CAT SENSORIMOTOR CORTEX NEURONS [J].

BATUEV, AS ;

ALEXANDROV, AA ;

SCHEYNIKOV, NA .

JOURNAL OF NEUROSCIENCE RESEARCH, 1982, 7 (01) :49-55

[6] GABAB RECEPTORS AND THEIR SIGNIFICANCE IN MAMMALIAN PHARMACOLOGY [J].

BOWERY, N .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1989, 10 (10) :401-407

[7] MEMBRANE-POTENTIAL CHANGES IN RAT SMI CORTICAL-NEURONS EVOKED BY CONTROLLED STIMULATION OF MYSTACIAL VIBRISSAE [J].

CARVELL, GE ;

SIMONS, DJ .

BRAIN RESEARCH, 1988, 448 (01) :186-191

[8] DISTRIBUTION AND KINETICS OF GABA-B BINDING-SITES IN RAT CENTRAL-NERVOUS-SYSTEM - A QUANTITATIVE AUTORADIOGRAPHIC STUDY [J].

CHU, DCM ;

ALBIN, RL ;

YOUNG, AB ;

PENNEY, JB .

NEUROSCIENCE, 1990, 34 (02) :341-357

[9] 2 INHIBITORY POSTSYNAPTIC POTENTIALS, AND GABAA AND GABAB RECEPTOR-MEDIATED RESPONSES IN NEOCORTEX OF RAT AND CAT [J].

CONNORS, BW ;

MALENKA, RC ;

SILVA, LR .

JOURNAL OF PHYSIOLOGY-LONDON, 1988, 406 :443-468

[10] FUNCTIONAL-ROLE OF GABA IN CAT PRIMARY SOMATOSENSORY CORTEX - SHAPING RECEPTIVE-FIELDS OF CORTICAL-NEURONS [J].

DYKES, RW ;

LANDRY, P ;

METHERATE, R ;

HICKS, TP .

JOURNAL OF NEUROPHYSIOLOGY, 1984, 52 (06) :1066-1093

← 1 2 →