A rapid brain metabolic change in infants detected by fMRI

被引：96

作者：

Yamada, H

Sadato, N

Konishi, Y

Kimura, K

Tanaka, M

Yonekura, Y

Ishii, Y

机构：

[1] FUKUI MED SCH,BIOMED IMAGING RES CTR,FUKUI 91011,JAPAN

[2] FUKUI MED SCH,DEPT PEDIAT,FUKUI 91011,JAPAN

来源：

NEUROREPORT | 1997年 / 8卷 / 17期

关键词：

brain activation; critical period; fMRI; infant; visual cortex;

D O I：

10.1097/00001756-199712010-00024

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To determine developmental changes of activity-related metabolism in human visual cortex, we performed functional magnetic resonance imaging (fMRI) from the neonatal period. A rapid metabolic changing pattern accompanying normal human brain maturation was revealed by fMRI with photic stimulation. Infants older than 8 weeks of age showed a stimulus-related signal decrease in the visual cortex, whereas younger neonates showed a signal increase. This inversion of response in infants suggests a change in oxygen consumption during neuronal activation, which is related to rapid synapse formation and accompanying increased metabolism. fMRI can detect dynamic metabolic changes during the brain maturation, and provides a new clue in the detection of abnormal brain development or CNS plasticity.

引用

页码：3775 / 3778

页数：4

共 23 条

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