Endothelial cell dysfunction and cardiac hypertrophy in the STOX1 model of preeclampsia

被引：41

作者：

Ducat, Aurelien ^{[1
,2
,3
,4
]}

Doridot, Ludivine ^{[1
,2
,3
,4
]}

Calicchio, Rosamaria ^{[1
,2
,3
,4
]}

Mehats, Celine ^{[1
,2
,3
,4
]}

Vilotte, Jean-Luc ^{[5
]}

Castille, Johann ^{[5
]}

Barbaux, Sandrine ^{[1
,2
,3
,4
]}

Couderc, Betty ^{[1
,2
,3
,4
]}

Jacques, Sebastien ^{[1
,2
,3
,4
]}

Letourneur, Franck ^{[1
,2
,3
,4
]}

Buffat, Christophe ^{[6
]}

Le Grand, Fabien ^{[1
,2
,3
,4
]}

Laissue, Paul ^{[7
]}

Miralles, Francisco ^{[1
,2
,3
,4
]}

Vaiman, Daniel ^{[1
,2
,3
,4
]}

机构：

[1] Inst Cochin, INSERM, U1016, Paris, France

[2] CNRS, UMR8104, Paris, France

[3] Univ Paris 05, Sorbonne Paris Cite, Paris, France

[4] PRES Sorbonne Paris Cite, DHU Risques & Grossesse, F-75014 Paris, France

[5] Inst Natl Rech Agron Jouy en Josas, Unite Mixtes Genet Anim & Biol Rech 1313, Jouy En Josas, France

[6] Hop Conception, Assistance Publ Hop Marseille, Genet & Endocrine Oncol, Marseille, France

[7] Univ Rosario, Unidad Genet, Grp GENIUROS, Escuela Med & Ciencias Salud, Bogota, Colombia

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

关键词：

EXPRESSION; RECEPTOR; ENDOMETRIOSIS; PATHOGENESIS; INHIBITION; MECHANISMS; DISEASE; ALPHA; CORIN;

D O I：

10.1038/srep19196

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Preeclampsia is a disease of pregnancy involving systemic endothelial dysfunction. However, cardiovascular consequences of preeclampsia are difficult to analyze in humans. The objective of the present study is to evaluate the cardiovascular dysfunction induced by preeclampsia by examining the endothelium of mice suffering of severe preeclampsia induced by STOX1 overexpression. Using Next Generation Sequencing on endothelial cells of mice carrying either transgenic or control embryos, we discovered significant alterations of gene networks involved in inflammation, cell cycle, and cardiac hypertrophy. In addition, the heart of the preeclamptic mice revealed cardiac hypertrophy associated with histological anomalies. Bioinformatics comparison of the networks of modified genes in the endothelial cells of the preeclamptic mice and HUVECs exposed to plasma from preeclamptic women identified striking similarities. The cardiovascular alterations in the pregnant mice are comparable to those endured by the cardiovascular system of preeclamptic women. The STOX1 mice could help to better understand the endothelial dysfunction in the context of preeclampsia, and guide the search for efficient therapies able to protect the maternal endothelium during the disease and its aftermath.

引用

页数：9

共 42 条

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