The EGFR as a target for viral oncoproteins

被引：32

作者：

Miller, WE ^{[1
]}

Raab-Traub, N

机构：

[1] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

[2] Univ N Carolina, Sch Med, Lineberger Comprehens Canc Ctr, Dept Microbiol, Chapel Hill, NC 27599 USA

来源：

TRENDS IN MICROBIOLOGY | 1999年 / 7卷 / 11期

关键词：

D O I：

10.1016/S0966-842X(99)01605-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The epidermal growth factor receptor (EGFR) is a potent stimulator of the mitogen-activated protein kinase (MAPK) signaling pathway. Chronic stimulation of the EGFR and of multiple steps in the MAPK signaling pathway is involved in the development of cancer. Several tumor viruses encode proteins that induce EGFR expression or stimulate EGFR-mediated signaling and are thus likely to play an important role in the transformation of virus-infected cells.

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收藏

页码：453 / 458

页数：6

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