Antimitochondrial activity displayed by the antimicrobial peptide microcin J25

被引：12

作者：

Chirou, MVN ^{[1
]}

Minahk, CJ ^{[1
]}

Morero, RD ^{[1
]}

机构：

[1] Univ Nacl Tucuman, Consejo Nacl Invest Cient & Tecn, Inst Super Invest Biol, Dept Bioquim & Nutr,Inst Quim Biol, RA-4000 San Miguel De Tucuman, Argentina

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2004年 / 317卷 / 03期

关键词：

D O I：

10.1016/j.bbrc.2004.03.127

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this report we studied the effect of the antimicrobial peptide, microcin J25, on the rat heart mitochondria. This peptide induced an important inhibition of the ATP synthesis with the concomitant enhancement of the ATP degradation. These effects were the result of two processes: on one hand, microcin 125 was able to insert into the membrane and hence alter its permeability with the consequent dissipation of the proton motive force. On the other. microcin J25 inhibited the enzymatic activity of the cytochrome c reductase (complex III) of the respiratory chain. The relevance of this study to the potential Use of microcin J25 as an anti-tumoral agent is discussed. (C) 2004 Elsevier hic. All rights reserved.

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页码：882 / 886

页数：5

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