Cephalosporin-derived inhibitors of β-lactamase.: Part 4:: The C3 substituent

被引：17

作者：

Buynak, JD ^{[1
]}

Vogeti, L ^{[1
]}

Doppalapudi, VR ^{[1
]}

Solomon, GM ^{[1
]}

Chen, HS ^{[1
]}

机构：

[1] So Methodist Univ, Dept Chem, Dallas, TX 75275 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 12期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0960-894X(02)00205-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New C3-substituted beta-lactamase inhibitors were prepared and evaluated against representative class A and class C enzymes. It was possible to improve simultaneous inhibitory activity of both classes of serine hydrolase. Other inhibitors showed high selectivity for either the class C cephalosporinases or the class A penicillinases. This represents the first time that cephalosporin-derived inhibitors have demonstrated selectivity for the class A beta-lactamases. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1663 / 1666

页数：4

共 14 条

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