Tra2 protein biology and mechanisms of splicing control

被引：14

作者：

Best, Andrew ^{[1
]}

Dalgliesh, Caroline ^{[1
]}

Kheirollahi-Kouhestani, Mahsa ^{[1
]}

Danilenko, Marina ^{[1
]}

Ehrmann, Ingrid ^{[1
]}

Tyson-Capper, Alison ^{[2
]}

Elliott, David J. ^{[1
]}

机构：

[1] Newcastle Univ, Inst Med Genet, Newcastle Upon Tyne NE1 3BZ, Tyne & Wear, England

[2] Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne NE1 3BZ, Tyne & Wear, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2014年 / 42卷

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

alternative splicing; Drosophila; gene expression; RNA recognition motif; RS domain; Tra2; PRE-MESSENGER-RNA; SEX DETERMINATION HIERARCHY; REGULATORY ELEMENTS; SITE SELECTION; AM-TRA2; GENE; DROSOPHILA; ENHANCER; TRA2-BETA; BINDING; SPERMATOGENESIS;

D O I：

10.1042/BST20140075

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tra2 proteins regulate pre-mRNA splicing in vertebrates and invertebrates, and are involved in important processes ranging from brain development in mice to sex determination in fruitflies. In structure Tra2 proteins contain two RS domains (domains enriched in arginine and serine residues) flanking a central RRM (RNA recognition motif). Understanding the mechanisms of how Tra2 proteins work to control splicing is one of the key requirements to understand their biology. In the present article, we review what is known about how Tra2 proteins regulate splicing decisions in mammals and fruitflies.

引用

页码：1152 / 1158

页数：7

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