5-Nitroimidazole derivatives as possible antibacterial and antifungal agents

被引：61

作者：

Günay, NS

Capan, G ^{[1
]}

Ulusoy, N

Ergenç, N

Ötük, G

Kaya, D

机构：

[1] Univ Istanbul, Fac Pharm, Dept Pharmaceut Chem, TR-34452 Istanbul, Turkey

[2] Univ Istanbul, Fac Pharm, Dept Pharmaceut Microbiol, TR-34452 Istanbul, Turkey

[3] Univ Istanbul, Fac Med, Dept Microbiol, TR-34390 Istanbul, Turkey

来源：

FARMACO | 1999年 / 54卷 / 11-12期

关键词：

5-nitroimidazoles; 1,2,4-triazoles; dithiocarbamates; antibacterial activity; antifungal activity;

D O I：

10.1016/S0014-827X(99)00109-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Some novel 1-[2-[[5-(2-furanyl)-4-substituted 4H-1,2,4-triazol-3-yl]thio]ethyl]-2-methyl-5-nitro-1H-imidazoles (3), 1-[3-[[5-(2-furanyl/2-thienyl)-4-substituted 4H-1,2,4-triazol-3-yl]-thio]-2-hydroxypropyl]-2-methyl-5-nitro-1H-imidazoles (5) and 1-[3-[(N,N-disubstituted thiocarbamoyl)-thio]-2-hydroxypropyl]-2-methyl-5-nitro-1H-imidazoles (7) were synthesized and evaluated for in vitro antibacterial and antifungal activity. Some of 5 were found to be effective against bacteria and fungi (minimum inhibitory concentration (MIC) 7.3-125 mu g/ml), whereas 7 were found to be effective against fungi (MIC 3-25 mu g/ml). (C) 1999 Elsevier Science S.A. AII rights reserved.

引用

页码：826 / 831

页数：6

共 24 条

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