The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis

被引：743

作者：

McAllister, Sandra S. ^{[1
,2
,3
,4
]}

Weinberg, Robert A. ^{[5
,6
]}

机构：

[1] Brigham & Womens Hosp, Div Hematol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

[3] Broad Inst Harvard & MIT, Cambridge, MA 02142 USA

[4] Harvard Stem Cell Inst, Cambridge, MA 02138 USA

[5] MIT, Dept Biol, Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[6] MIT Ludwig Ctr Mol Oncol, Cambridge, MA 02142 USA

来源：

NATURE CELL BIOLOGY | 2014年 / 16卷 / 08期

基金：

美国国家卫生研究院;

关键词：

ENDOTHELIAL PROGENITOR CELLS; NEUTROPHIL-LYMPHOCYTE RATIO; GR-1+CD11B+ MYELOID CELLS; PLATELET ALPHA-GRANULES; MESENCHYMAL STEM-CELLS; BREAST-CANCER; BONE-MARROW; PREMETASTATIC NICHE; HEMATOPOIETIC STEM; INFLAMMATORY SITES;

D O I：

10.1038/ncb3015

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent pre-clinical and clinical research has provided evidence that cancer progression is driven not only by a tumour's underlying genetic alterations and paracrine interactions within the tumour microenvironment, but also by complex systemic processes. We review these emerging paradigms of cancer pathophysiology and discuss how a clearer understanding of systemic regulation of cancer progression could guide development of new therapeutic modalities and efforts to prevent disease relapse following initial diagnosis and treatment.

引用

页码：717 / 727

页数：11

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