Regulation of JNK by Src during Drosophila development

被引：114

作者：

Tateno, M ^{[1
]}

Nishida, Y ^{[1
]}

Adachi-Yamada, T ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Sci, Div Biol Sci, Chikusa Ku, Nagoya, Aichi 4648602, Japan

来源：

SCIENCE | 2000年 / 287卷 / 5451期

关键词：

D O I：

10.1126/science.287.5451.324

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In Drosophila, the Jun amino-terminal kinase (JNK) homolog Basket (Bsk) is required for epidermal closure. Mutants for Src42A, a Drosophila c-src protooncogene homolog, are described. Src42A functions in epidermal closure during both embryogenesis and metamorphosis. The severity of the epidermal closure defect in the Src42A mutant depended on the amount of Bsk activity, and the amount of Bsk activity depended. on the amount of Src42A. Thus, activation of the Bsk pathway is required downstream of Src42A in epidermal closure. This work confirms mammalian studies that demonstrated a physiological link between Src and JNK.

引用

页码：324 / 327

页数：4

共 36 条

[1]

BRAND AH, 1993, DEVELOPMENT, V118, P401

[2] PATTERNING OF THE DROSOPHILA NERVOUS-SYSTEM - THE ACHAETE-SCUTE GENE-COMPLEX [J].

CAMPUZANO, S ;

MODOLELL, J .

TRENDS IN GENETICS, 1992, 8 (06) :202-208

[3] CELL-TRANSFORMATION BY PP60C-SRC MUTATED IN THE CARBOXY-TERMINAL REGULATORY DOMAIN [J].

CARTWRIGHT, CA ;

ECKHART, W ;

SIMON, S ;

KAPLAN, PL .

CELL, 1987, 49 (01) :83-91

[4]

Dodson GS, 1998, DEVELOPMENT, V125, P2883

[5] HEMIPTEROUS ENCODES A NOVEL DROSOPHILA MAP KINASE KINASE, REQUIRED FOR EPITHELIAL-CELL SHEET MOVEMENT [J].

GLISE, B ;

BOURBON, H ;

NOSELLI, S .

CELL, 1995, 83 (03) :451-461

[6] SRC64 regulates the localization of a tec-family kinase required for Drosophila ring canal growth [J].

Guarnieri, DJ ;

Dodson, GS ;

Simon, MA .

MOLECULAR CELL, 1998, 1 (06) :831-840

[7] CD66-mediated phagocytosis of Opa52 Neisseria gonorrhoeae requires a Src-like tyrosine kinase- and Rac1-dependent signalling pathway [J].

Hauck, CR ;

Meyer, TF ;

Lang, F ;

Gulbins, E .

EMBO JOURNAL, 1998, 17 (02) :443-454

[8] Drosophila Jun relays the Jun amino-terminal kinase signal transduction pathway to the decapentaplegic signal transduction pathway in regulating epithelial cell sheet movement [J].

Hou, XS ;

Goldstein, ES ;

Perrimon, N .

GENES & DEVELOPMENT, 1997, 11 (13) :1728-1737

[9] CRYSTAL-STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HUMAN INSULIN-RECEPTOR [J].

HUBBARD, SR ;

WEI, L ;

ELIS, L ;

HENDRICKSON, WA .

NATURE, 1994, 372 (6508) :746-754

[10] Signal transduction by the c-Jun N-terminal kinase (JNK) - from inflammation to development [J].

Ip, YT ;

Davis, RJ .

CURRENT OPINION IN CELL BIOLOGY, 1998, 10 (02) :205-219

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