Src and the control of cell division

被引:66
作者
Taylor, SJ
Shalloway, D
机构
[1] Sect. Biochem., Molec./Cell Biol., Cornell University, Ithaca
关键词
D O I
10.1002/bies.950180105
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The finely tuned mechanisms that control cell cycle progression go awry in cancer, pointing to proto-oncogene products as important players in cell-cycle regulation. One such proto-oncoprotein, c-Src, has previously been directly implicated, based on its requirement for growth factor-stimulated DNA synthesis. Roche et al.((1)) have now shown that c-Src or its close relatives are also required for cell division to occur. The demonstration of essential functions for the Src family at multiple points in the cell cycle raises important questions about the normal and transforming activities of these and other proto-oncoproteins.
引用
收藏
页码:9 / 11
页数:3
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