The finely tuned mechanisms that control cell cycle progression go awry in cancer, pointing to proto-oncogene products as important players in cell-cycle regulation. One such proto-oncoprotein, c-Src, has previously been directly implicated, based on its requirement for growth factor-stimulated DNA synthesis. Roche et al.((1)) have now shown that c-Src or its close relatives are also required for cell division to occur. The demonstration of essential functions for the Src family at multiple points in the cell cycle raises important questions about the normal and transforming activities of these and other proto-oncoproteins.
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NATL RES COUNCIL CANADA, DIV BIOL SCI, CELL PHYSIOL GRP, OTTAWA K1A 0R6, ONTARIO, CANADANATL RES COUNCIL CANADA, DIV BIOL SCI, CELL PHYSIOL GRP, OTTAWA K1A 0R6, ONTARIO, CANADA
DURKIN, JP
WHITFIELD, JF
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NATL RES COUNCIL CANADA, DIV BIOL SCI, CELL PHYSIOL GRP, OTTAWA K1A 0R6, ONTARIO, CANADANATL RES COUNCIL CANADA, DIV BIOL SCI, CELL PHYSIOL GRP, OTTAWA K1A 0R6, ONTARIO, CANADA
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NATL RES COUNCIL CANADA, DIV BIOL SCI, CELL PHYSIOL GRP, OTTAWA K1A 0R6, ONTARIO, CANADANATL RES COUNCIL CANADA, DIV BIOL SCI, CELL PHYSIOL GRP, OTTAWA K1A 0R6, ONTARIO, CANADA
DURKIN, JP
WHITFIELD, JF
论文数: 0引用数: 0
h-index: 0
机构:
NATL RES COUNCIL CANADA, DIV BIOL SCI, CELL PHYSIOL GRP, OTTAWA K1A 0R6, ONTARIO, CANADANATL RES COUNCIL CANADA, DIV BIOL SCI, CELL PHYSIOL GRP, OTTAWA K1A 0R6, ONTARIO, CANADA