学术探索
学术期刊
新闻热点
数据分析
智能评审

In vivo pharmacokinetics of phosphorothioate oligonucleotides containing contiguous guanosines

被引：27
作者：
Agrawal, S
Tan, WT
Cai, QY
Xie, XW
Zhang, RW
机构：
[1] UNIV ALABAMA,DIV CLIN PHARMACOL,BIRMINGHAM,AL 35294
[2] UNIV ALABAMA,DEPT PHARMACOL & TOXICOLOTY,BIRMINGHAM,AL 35294
来源：
ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT | 1997年 / 7卷 / 03期
关键词：
D O I：
10.1089/oli.1.1997.7.245
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：245 / 249
页数：5
相关论文
共 19 条
  • [1] PHARMACOKINETICS, BIODISTRIBUTION, AND STABILITY OF OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATES IN MICE
    AGRAWAL, S
    TEMSAMANI, J
    TANG, JY
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (17) : 7595 - 7599
  • [2] Effect of G-rich sequences on the synthesis, purification, hybridization, cell uptake, and hemolytic activity of oligonucleotides
    Agrawal, S
    Iadarola, PL
    Temsamani, J
    Zhao, QY
    Shaw, DR
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (18) : 2219 - 2224
  • [3] Mixed-backbone oligonucleotides as second generation antisense oligonucleotides: In vitro and in vivo studies
    Agrawal, S
    Jiang, ZW
    Zhao, QY
    Shaw, D
    Cai, QY
    Roskey, A
    Channavajjala, L
    Saxinger, C
    Zhang, RW
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (06) : 2620 - 2625
  • [4] Antisense oligonucleotides: Towards clinical trials
    Agrawal, S
    [J]. TRENDS IN BIOTECHNOLOGY, 1996, 14 (10) : 376 - 387
  • [5] ABSORPTION, TISSUE DISTRIBUTION AND IN-VIVO STABILITY IN RATS OF A HYBRID ANTISENSE OLIGONUCLEOTIDE FOLLOWING ORAL-ADMINISTRATION
    AGRAWAL, S
    ZHANG, XS
    LU, ZH
    ZHAO, H
    TAMBURIN, JM
    YAN, YM
    CAI, HY
    DIASIO, RB
    HABUS, I
    JIANG, ZW
    IYER, RP
    YU, D
    ZHANG, RW
    [J]. BIOCHEMICAL PHARMACOLOGY, 1995, 50 (04) : 571 - 576
  • [6] PHARMACOKINETICS OF ANTISENSE OLIGONUCLEOTIDES
    AGRAWAL, S
    TEMSAMANI, J
    GALBRAITH, W
    TANG, JY
    [J]. CLINICAL PHARMACOKINETICS, 1995, 28 (01) : 7 - 16
  • [7] AGRAWAL S, 1996, ANTISENSE OLIGONUCLE, P60
  • [8] In vivo studies with antisense oligonucleotides
    Akhtar, S
    Agrawal, S
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1997, 18 (01) : 12 - 18
  • [9] COSSUM PA, 1993, J PHARMACOL EXP THER, V267, P1181
  • [10] PHARMACOKINETICS OF AN ANTISENSE PHOSPHOROTHIOATE OLIGODEOXYNUCLEOTIDE AGAINST REV FROM HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 IN THE ADULT MALE-RAT FOLLOWING SINGLE INJECTIONS AND CONTINUOUS-INFUSION
    IVERSEN, PL
    MATA, J
    TRACEWELL, WG
    ZON, G
    [J]. ANTISENSE RESEARCH AND DEVELOPMENT, 1994, 4 (01): : 43 - 52
12