Apoptosis and impaired axonal regeneration of sensory neurons after nerve crush in diabetic rats

被引：29

作者：

Kogawa, S ^{[1
]}

Yasuda, H ^{[1
]}

Terada, M ^{[1
]}

Maeda, K ^{[1
]}

Kikkawa, R ^{[1
]}

机构：

[1] Shiga Univ Med Sci, Dept Med 3, Shiga 5202192, Japan

来源：

NEUROREPORT | 2000年 / 11卷 / 04期

关键词：

apoptosis; c-jun; c-jun N-terminal kinase; cyclic AMP; diabetic rats; dorsal root ganglion; nerve regeneration; prostaglandin E-1;

D O I：

10.1097/00001756-200003200-00003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated the possible induction of apoptosis of dorsal root ganglion (DRG) neurons and the defect of nerve regeneration after crush injury with reference to the JNK/c-jun and cAMP pathway in streptozocin-induced diabetic rats. In addition, the effects of a PGE(1) analogue were tested in diabetic rats. At day 0 (before axonal injury), no TUNEL-positive DRG neurons were observed in any group. From day 1 to 7 after axonal injury, TUNEL-positive DRG neurons were seen in diabetic rats, but not in non-diabetic or PGE(1)-treated diabetic rats. The regeneration distance at day 7 after crush injury was shorter in diabetic rats than in the other groups of rats. The time course of JNK/c-jun phosphorylation did not parallel apoptosis. At day 7, the cAMP content of DRG was higher than that at day 0 in non-diabetic and PGE(1)-treated rats, whereas it was not increased after 7 days in diabetic rats. These results indicate that in diabetic rats apoptosis of DRG neurons is induced by axonal injury independently of the JNK/c-jun and cAMP pathway and that PGE(1) rescues DRG neurons from apoptosis and improves axonal regeneration in diabetic rats. NeuroReport 11:663-667 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：663 / 667

页数：5

共 24 条

[1] MYELINATED NERVE-FIBER REGENERATION IN DIABETIC SENSORY POLYNEUROPATHY - CORRELATION WITH TYPE OF DIABETES [J].