Trichosporon beigelii:: a life-threatening pathogen in immunocompromised hosts

被引：62

作者：

Erer, B

Galimberti, M

Lucarelli, G

Giardini, C

Polchi, P

Baronciani, D

Gaziev, D

Angelucci, E

Izzi, G

机构：

[1] Div Ematol, I-61100 Pesaro, Italy

[2] Ctr Trapianti Midollo Osseo Muraglia, I-61100 Pesaro, Italy

[3] Osped Parma, Div Oncoematol Pediat, Parma, Italy

来源：

BONE MARROW TRANSPLANTATION | 2000年 / 25卷 / 07期

关键词：

Tricosporon beigelii; bone marrow transplantation; immunosuppression;

D O I：

10.1038/sj.bmt.1702231

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Patients undergoing bone marrow transplantation are profoundly immunosuppressed as a result of their intensive myeloablative chemotherapy and are at high risk for opportunistic fungal infections mainly caused by Candida spp and Aspergillus spp. Trichosporon beigelii (T beigelii) has emerged as a life-threatening opportunistic pathogen in granulocytopenic and immunocompromised hosts and there is a marked increase in cases reported in the literature. Response to antifungal agents is poor, mortality is high and immunological recovery is the most important factor for a favorable outcome in patients with trichosporonosis. We present three cases of T, beigelii infection in patients undergoing allogeneic bone marrow transplantation in our center and we review cases described in the literature.

引用

页码：745 / 749

页数：5

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