Emerging role of bone morphogenetic proteins in angiogenesis

被引：249

作者：

David, Laurent ^{[2
,3
]}

Feige, Jean-Jacques ^{[2
,3
]}

Bailly, Sabine ^{[1
,2
,3
]}

机构：

[1] Commissariat Energie Atom, Inst Rech Technol & Sci Vivant LAPV, U878, F-38054 Grenoble, France

[2] Inst Natl Sante & Rech Med, U878, F-38054 Grenoble, France

[3] Univ Grenoble 1, Grenoble, France

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2009年 / 20卷 / 03期

关键词：

BMP; Receptors; Angiogenesis; HHT; PAH; HEREDITARY HEMORRHAGIC TELANGIECTASIA; PRIMARY PULMONARY-HYPERTENSION; RECEPTOR-LIKE KINASE-1; GROWTH-FACTOR-BETA; SMOOTH-MUSCLE-CELLS; TGF-BETA; ENDOTHELIAL-CELLS; GENE-EXPRESSION; ARTERIAL-HYPERTENSION; OSTEOGENIC PROTEIN-1;

D O I：

10.1016/j.cytogfr.2009.05.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bone morphogenetic proteins (BMPs) are Multifunctional growth factors belonging to the transforming growth factor beta (TGF beta) superfamily. Recent observations clearly emphasize the emerging role of BMPs in angiogenesis: (i) two genetic vascular diseases (hereditary hemorrhagic telangiectasia (HHT) and pulmonary arterial hypertension (PAH)) are caused by mutations in genes encoding components of the BMP signalling pathway (endoglin, ALK1 and BMPRII). (ii) BMP9 has been identified as the physiological ligand of the endothelial receptor ALK1 in association with BMPRII. This review will focus on the diverse functions of BMPs in angiogenesis. We will propose a model that distinguishes the BMP2, BMP7 and GDF5 subgroups from the BMP9 subgroup on the basis of their functional implication in the two phases of angiogenesis (activation and maturation). (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：203 / 212

页数：10

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