Migraine with aura is not linked to the FHM gene CACNA1A or the chromosomal region, 19p13

被引：27

作者：

Noble-Topham, SE

Dyment, DA

Cader, MZ

Ganapathy, R

Brown, JD

Rice, GPA

Ebers, GC

机构：

[1] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX2 6HE, England

[2] Univ Western Ontario, Dept Microbiol, London, ON, Canada

[3] Univ Western Ontario, London Hlth Sci Ctr, London, ON, Canada

[4] Univ Western Ontario, Dept Clin Neurol Sci, London, ON, Canada

[5] Univ Western Ontario, Lawson Hlth Res Inst, London, ON, Canada

[6] Univ Oxford, Radcliffe Infirm, Dept Clin Neurol, Oxford OX2 6HE, England

来源：

NEUROLOGY | 2002年 / 59卷 / 07期

关键词：

D O I：

10.1212/WNL.59.7.1099

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Two microsatellite markers, tightly linked to CACNA1A, were genotyped in migraine with aura (MA) families to determine if this gene, which underlies the 19p13 linked forms of familial hemiplegic migraine, is also linked to MA. Two-point parametric lod and nonparametric linkage scores did not support linkage. Transmission disequilibrium testing provided no evidence for linkage of MA to CACNA1A. In a large dataset of 64 Canadian MA families, the authors did not find evidence to support an MA susceptibility gene in the region of 19p13.

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页码：1099 / 1101

页数：3

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