Ubiquitin-related modifier SUMO1 and nucleocytoplasmic transport

被引：161

作者：

Pichler, A ^{[1
]}

Melchior, F ^{[1
]}

机构：

[1] Max Planck Inst Biochem, D-82152 Martinsried, Germany

来源：

TRAFFIC | 2002年 / 3卷 / 06期

关键词：

E3-ligase; isopeptidase; nuclear protein import; nucleocytoplasmic transport; PIAS; RanBP2; RanGAP1; Smt3; SUMO1; Ubc9; ubiquitin;

D O I：

10.1034/j.1600-0854.2002.30601.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Small ubiquitin related modifier SUMO-1 and its homologs can be conjugated to a large number of cellular proteins. This involves an enzymatic cascade that resembles ubiquitination, and the modification can be reverted by isopeptidases. SUMOylation does not lead to degradation but instead appears to regulate protein/protein interactions, intracellular localization and protects some modified targets from ubiquitin-dependent degradation. Data collected for more than 30 different target proteins point to two cellular processes, nucleocytoplasmic transport and intranuclear targeting, in which SUMO plays an active role. Here we will focus on links between SUMO and nuclear transport.

引用

页码：381 / 387

页数：7

共 54 条

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