Negative regulation of Toll-like receptor signaling pathway

被引：136

作者：

Wang, Jie ^{[1
]}

Hu, Yu ^{[1
]}

Deng, Wei Wen ^{[1
]}

Sun, Bing ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China

[2] Chinese Acad Sci, Inst Pasteur Shanghai, Shanghai Inst Biol Sci, Shanghai 200025, Peoples R China

来源：

MICROBES AND INFECTION | 2009年 / 11卷 / 03期

基金：

中国国家自然科学基金;

关键词：

TLR; Negative regulation; Degradation; Deubiquitination; NF-KAPPA-B; I INTERFERON; DC-SIGN; RESPONSES; INNATE; TOLL-LIKE-RECEPTOR-4; DEGRADATION; ACTIVATION; SUPPRESSOR; MYD88;

D O I：

10.1016/j.micinf.2008.12.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

TLRs are primary sensors of invading pathogens, recognizing conserved microbial molecules and activating signaling pathways that are pivotal to innate and adaptive immune responses. However, a TLR signaling pathway must be tightly controlled because its excessive activation can contribute to the pathogenesis of many human diseases. This review provides a summary of the different mechanisms that are involved in the negative regulation of TLR signaling pathways. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

收藏

页码：321 / 327

页数：7

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