The synthesis and antitumor evaluation of unsymmetrical bis-imides

被引：18

作者：

Cherney, RJ

Swartz, SG

Patten, AD

Akamike, E

Sun, JH

Kaltenbach, RF

Seitz, SP

Behrens, CH

Getahun, Z

Trainor, GL

Vavala, M

Kirshenbaum, MR

Papp, LM

Stafford, MP

Czerniak, PM

Diamond, RJ

McRipley, RJ

Page, RJ

Gross, JL

机构：

[1] DuPont Merck Pharmaceutical Co. E., Wilmington

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(96)00591-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Unsymmetrical bis-imides 1 were synthesized and evaluated as potential antitumor agents. These novel bis-imides were assessed using three criteria: in vitro cytotoxicity (L1210), in vitro DNA binding, and in vivo studies with human tumor xenografts in mice. These studies identified DMP 315 as a potent, water soluble antitumor agent. (C) 1997, Elsevier Science Ltd.

引用

页码：163 / 168

页数：6

共 16 条

[1] METHODS FOR THE SELECTIVE MODIFICATION OF SPERMIDINE AND ITS HOMOLOGS
BERGERON, RJ
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1986, 19 (04) : 105 - 113
[2] BOUSQUET PF, 1995, CANCER RES, V55, P1176
[3] PREPARATION OF DIAMINO ETHERS AND POLYAMINES
BRADSHAW, JS
KRAKOWIAK, KE
IZATT, RM
[J]. TETRAHEDRON, 1992, 48 (22) : 4475 - 4515
[4] USING CELL-FRACTIONATION AND PHOTOCHEMICAL CROSS-LINKING METHODS TO DETERMINE THE CELLULAR-BINDING SITE(S) OF THE ANTITUMOR DRUG DMP-840
CHATTERJEE, PK
STERNBERG, NL
[J]. PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1995, 61 (04) : 360 - 366
[5] XB596, A PROMISING BIS-NAPHTHALIMIDE ANTICANCER AGENT
CHEN, SF
BEHRENS, DL
BEHRENS, CH
CZERNIAK, PM
DEXTER, DL
DUSAK, BL
FREDERICKS, JR
GALE, KC
GROSS, JL
JIANG, JB
KIRSHENBAUM, MR
MCRIPLEY, RJ
PAPP, LM
PATTEN, AD
PERRELLA, FW
SEITZ, SP
STAFFORD, MP
SUN, JH
SUN, T
WUONOLA, MA
VONHOFF, DD
[J]. ANTI-CANCER DRUGS, 1993, 4 (04) : 447 - 457
[6] FUJINO M, 1981, CHEM PHARM BULL, V29, P2825
[7] NEW CHEMISTRY OF NATURALLY-OCCURRING POLYAMINES
GANEM, B
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1982, 15 (09) : 290 - 298
[8] HETEROCYCLIC DERIVATIVES OF NAPHTHALENE-1,8-DICARBOXYLIC ANHYDRIDE .2. COLOR AND DYEING PROPERTIES ON SYNTHETIC-FIBERS OF SOME SUBSTITUTED 7H-BENZIMIDAZO[2,1-A]BENZ[DE]ISOQUINOLIN-7-ONES
GRAYSHAN, PH
PETERS, AT
[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1973, 10 (05) : 705 - 710
[9] KIRSHENBAUM MR, 1994, CANCER RES, V54, P2199
[10] MONO-PROTECTED DIAMINES - N-TERT-BUTOXYCARBONYL-ALPHA,OMEGA-ALKANEDIAMINES FROM ALPHA,OMEGA-ALKANEDIAMINES
KRAPCHO, AP
KUELL, CS
[J]. SYNTHETIC COMMUNICATIONS, 1990, 20 (16) : 2559 - 2564

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