Predictive accuracy and explained variation in Cox regression

被引:169
作者
Schemper, M
机构
[1] Univ Vienna, Dept Med Comp Sci, Sect Clin Biometr, A-1090 Vienna, Austria
[2] Univ Lancaster, Dept Math & Stat, Lancaster LA1 4YF, England
关键词
censored data; Cox regression; explained variation; prediction error; survival analysis;
D O I
10.1111/j.0006-341X.2000.00249.x
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
We suggest a new measure of the proportion of the variation of possibly censored survival times explained by a given proportional hazards model. The proposed measure, termed V, shares several favorable properties with an earlier V-1 but also improves the handling of censoring. The statistic contrasts distance measures between individual 1/0 survival processes and fitted survival curves with and without covariate information. These distance measures, D-x and D, respectively, are themselves informative as summaries of absolute rather than relative predictive accuracy. We recommend graphical comparisons of survival curves for prognostic index groups to improve the understanding of obtained values for V, D-x, and D. Their use and interpretation is exemplified for a Yorkshire lung cancer study on survival. From this and an overview for several well-known clinical data sets, we show that the likely amount of relative or absolute predictive accuracy is often low even if there are highly significant and relatively strong prognostic factors.
引用
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页码:249 / 255
页数:7
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