Palladium-catalyzed cross-coupling of terminal alkynes with 4-trifloyloxazole: Studies toward the construction of the C26-C31 subunit of phorboxazole A

被引:60
作者
Schaus, JV [1 ]
Panek, JS [1 ]
机构
[1] Boston Univ, Dept Chem, Metcalf Ctr Sci & Engn, Boston, MA 02215 USA
关键词
D O I
10.1021/ol991306h
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
[GRAPHICS] A strategy has been developed that successfully takes advantage of transition-metal-catalyzed coupling reactions for the synthesis of highly functionalized oxazoles. Trifloyloxazoles have been used as coupling partners with alkyne-derived vinylmetallic intermediates in Stille- and Negishi-type couplings to assemble the corresponding oxazoles in good isolated yield. The results obtained provide a close analogy and thus good precedent to employ this strategy in the synthesis of the oxazole subunits of phorboxazole A.
引用
收藏
页码:469 / 471
页数:3
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