Specificity on a knife-edge:: the αβ T cell receptor

被引:33
作者
Clements, Craig S.
Dunstone, Michelle A.
Macdonald, Whitney A.
McCluskey, James [1 ]
Rossjohn, Jamie
机构
[1] Monash Univ, Sch Biomed Sci, Prot Crystallog Unit, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia
[2] Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic 3010, Australia
基金
英国医学研究理事会; 澳大利亚研究理事会;
关键词
D O I
10.1016/j.sbi.2006.09.004
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The interaction between the up T cell receptor (TCR) and the peptide bound to the major histocompatibility complex class I molecule (pMHC-I) constitutes a central interaction in adaptive immunity. How these receptors interact with such low affinity while maintaining exquisite specificity for peptide antigen and host MHC (MHC-I restriction) remains a challenge to be explained by structural immunologists. Moreover, how this extracellular interaction is transmitted as an intracellular signal via the CD3 complex remains unresolved. Nevertheless, several structures of TCRs, non-liganded and ligated to a defined pMHC-I, combined with detailed biophysical analyses, have provided insight of the structural basis of MHC-I restriction. In addition, structures of isolated CD3 components have enabled T cell signalling mechanisms to be postulated. Recent findings in this area, which include seven distinct TCR/pMHC-I complexes, have fundamental implications in adaptive immunity as well as therapeutic applications to modulate the adaptive immune response.
引用
收藏
页码:787 / 795
页数:9
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