Controlled release of cytarabine from poly(2-hydroxyethyl methacrylate-co-N-vinyl-2-pyrrolidone) hydrogels

被引：31

作者：

Blanco, MD ^{[1
]}

Trigo, RM ^{[1
]}

Garcia, O ^{[1
]}

Teijon, JM ^{[1
]}

机构：

[1] UNIV COMPLUTENSE MADRID, FAC MED, DEPT BIOQUIM & BIOL MOL, E-28040 MADRID, SPAIN

来源：

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | 1997年 / 8卷 / 09期

关键词：

controlled release; hydrogel; poly(2-hydroxyethyl methacrylate-co-N-vinyl-2-pyrrolidone); cytarabine;

D O I：

10.1163/156856297X00515

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Controlled release of cytarabine (ara-C) from poly(2-hydroxyethyl methaclylate-co-N-vinyl-2-pyrrolidone) [p(HEMA-co-VP)] hydrogels cross-linked with ethylene glycol dimethacrylate (EGDMA) is reported. Three compositions of copolymer, each one with a different cross-linking degree, have been studied: H50/VP50, H75/VP25, and H80/VP20. Ara-C (5-25 mg by disc) was trapped in the gels by including it in the polymerization feed mixture. The ara-C release time was between 1 day from H50/VP50/E0.5 discs and 16 days from H80/VP20/E15 discs. In all cases there is a time period for which the drug release rate is constant.

引用

页码：709 / 719

页数：11

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