DNA microarray technology in nutraceutical and food safety

被引：69

作者：

Liu-Stratton, YL

Roy, S

Sen, CK

机构：

[1] Ohio State Univ, Med Ctr, Mol Med Lab, Columbus, OH 43210 USA

[2] Ohio State Univ, Med Ctr, DNA Microarray & Genet Facil, Dept Surg,Dorothy M Davis Heart & Lung Res Inst, Columbus, OH 43210 USA

来源：

TOXICOLOGY LETTERS | 2004年 / 150卷 / 01期

关键词：

nutrition; diet; safety; toxin; diagnosis; infection; genomics; microarray;

D O I：

10.1016/j.toxlet.2003.08.009

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 [卫生毒理学];

摘要：

The quality and quantity of diet is a key determinant of health and disease. Molecular diagnostics may play a key role in food safety related to genetically modified foods, food-borne pathogens and novel nutraceuticals. Functional outcomes in biology are determined, for the most part, by net balance between sets of genes related to the specific outcome in question. The DNA microarray technology offers a new dimension of strength in molecular diagnostics by permitting the simultaneous analysis of large sets of genes. Automation of assay and novel bioinformatics tools make DNA microarrays a robust technology for diagnostics. Since its development a few years ago, this technology has been used for the applications of toxicogenomics, pharmacogenomics, cell biology, and clinical investigations addressing the prevention and intervention of diseases. Optimization of this technology to specifically address food safety is a vast resource that remains to be mined. Efforts to develop diagnostic custom arrays and simplified bioinformatics tools for field use are warranted. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：29 / 42

页数：14

共 105 条

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