The effect of dexamethasone upon patient-controlled analgesia-related nausea and vomiting

被引:31
作者
Lee, Y
Lin, YS
Chen, YH
机构
[1] Tzu Chi Univ, Tzu Chi Med Ctr, Sch Med, Dept Anaesthesiol, Hualien, Taiwan
[2] Tzu Chi Univ, Tzu Chi Med Ctr, Sch Med, Dept Orthopaed, Hualien, Taiwan
关键词
analgesia; patient-controlled; pain; postoperative; vomiting; nausea; anti-emetics; dexamethasone;
D O I
10.1046/j.1365-2044.2002.02572_5.x
中图分类号
R614 [麻醉学];
学科分类号
100217 [麻醉学];
摘要
Ninety female patients were enrolled in this randomised, double-blind, placebo-controlled study to compare the anti-emetic effect of intravenous dexamethasone 8 mg with saline control in preventing patient-controlled analgesia-related nausea and vomiting following major orthopaedic surgery. The prophylactic administration of dexamethasone 8 mg significantly reduced the overall incidence of patient-controlled analgesia-related nausea and vomiting (p < 0.001) and the need for rescue anti-emetics (p < 0.01). Furthermore, patients who received dexamethasone showed a higher incidence of complete responses (no vomiting or need for rescue anti-emetic for a 24-h postoperative period) than those who received saline (p < 0.05). We conclude that dexamethasone 8 mg may be valuable for preventing patient-controlled analgesia-related nausea and vomiting in women undergoing major orthopaedic surgery.
引用
收藏
页码:705 / 709
页数:5
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