The ups and downs of p53: understanding protein dynamics in single cells

被引：190

作者：

Batchelor, Eric ^{[1
]}

Loewer, Alexander ^{[1
]}

Lahav, Galit ^{[1
]}

机构：

[1] Harvard Med Sch Syst Biol, Boston, MA 02115 USA

来源：

NATURE REVIEWS CANCER | 2009年 / 9卷 / 05期

基金：

美国国家卫生研究院;

关键词：

ACCELERATES TUMOR-FORMATION; P53-MDM2 FEEDBACK LOOP; DNA-DAMAGE RESPONSE; MDM2; SNP309; IN-VIVO; NUCLEOTIDE POLYMORPHISM; PHOSPHORYLATION; ATM; OSCILLATIONS; ACTIVATION;

D O I：

10.1038/nrc2604

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Cells living in a complex environment must constantly detect, process and appropriately respond to changing signals. Therefore, all cellular information processing is dynamic in nature. As a consequence. understanding the process of signal transduction often requires detailed quantitative analysis of dynamic behaviours. Here, we focus on the oscillatory dynamics of the tumour suppressor protein p53 as a model for studying protein dynamics in single cells to better understand its regulation and function.

引用

收藏

页码：371 / 377

页数：7

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