Antibiotic effectiveness: Balancing conservation against innovation

被引：148

作者：

Laxminarayan, Ramanan ^{[1
,2
,3
]}

机构：

[1] Ctr Dis Dynam Econ & Policy, Washington, DC 20036 USA

[2] Princeton Environm Inst, Princeton, NJ USA

[3] Publ Hlth Fdn India, New Delhi, India

来源：

SCIENCE | 2014年 / 345卷 / 6202期

关键词：

RESISTANCE; AZITHROMYCIN; VACCINE; PART;

D O I：

10.1126/science.1254163

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Antibiotic effectiveness is a natural societal resource that is diminished by antibiotic use. As with other such assets, keeping it available requires both conservation and innovation. Conservation encompasses making the best use of current antibiotic effectiveness by reducing demand through vaccination, infection control, diagnostics, public education, incentives for clinicians to prescribe fewer antibiotics, and restrictions on access to newer, last-resort antibiotics. Innovation includes improving the efficacy of current drugs and replenishing effectiveness by developing new drugs. In this paper, I assess the relative benefits and costs of these two approaches to maintaining our ability to treat infections.

引用

页码：1299 / 1301

页数：3

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