Cardiovascular effects of isorhamnetin and quercetin in isolated rat and porcine vascular smooth muscle and isolated rat atria

被引：52

作者：

Ibarra, M

Pérez-Vizcaíno, F

Cogolludo, A

Duarte, J

Zaragozá-Arnaez, F

López-López, JG

Tamargo, J

机构：

[1] Univ Complutense Madrid, Sch Med, Dept Pharmacol, Madrid, Spain

[2] Univ Alcala de Henares, Sch Pharm, Dept Pharmacol, Madrid, Spain

[3] Univ Granada, Sch Pharm, Dept Pharmacol, Granada, Spain

来源：

PLANTA MEDICA | 2002年 / 68卷 / 04期

关键词：

quercetin; isorhamnetin; atria; coronary artery; portal vein;

D O I：

10.1055/s-2002-26752

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Isorhamnetin and quercetin produced endothelium-independent vasodilator effects in rat aorta, rat mesenteric arteries, rat portal vein and porcine coronary arteries. The effects of the two flavonoids were similar in arteries stimulated by noradrenaline, KCI, U46619 or phorbol esters but the two flavonoids were more potent in the coronary arteries than in the aorta. At high concentrations, they also induced a positive inotropic effect in isolated rat atria. Therefore, at least part of the in vivo effects of quercetin may result from its conversion to isorhamnetin which is the main metabolite of quercetin found in plasma. The arterial, venous and coronary vasodilator effects may contribute to the protective effects of flavonoids in ischaemic heart disease observed in epidemiological studies.

引用

页码：307 / 310

页数：4

共 9 条

[1] VASODILATOR EFFECTS OF QUERCETIN IN ISOLATED RAT VASCULAR SMOOTH-MUSCLE [J].