Sensing the heat: The application of isothermal titration calorimetry to thermodynamic studies of biomolecular interactions

被引：295

作者：

Ladbury, JE ^{[1
]}

Chowdhry, BZ ^{[1
]}

机构：

[1] UNIV GREENWICH, SCH BIOL & CHEM SCI, LONDON SE18 6PF, ENGLAND

来源：

CHEMISTRY & BIOLOGY | 1996年 / 3卷 / 10期

关键词：

D O I：

10.1016/S1074-5521(96)90063-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biomolecular interactions can be defined by combining thermodynamic data on the energetic properties of the interaction with high-resolution structural data. The development of high sensitivity isothermal titration calorimetric equipment provides a dramatic advance in the gathering of thermodynamic data, and the interactions between biological macromolecules can now be described with unprecedented accuracy.

引用

页码：791 / 801

页数：11

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