Peripheral non-opioid analgesic effects of kyotorphin in mice

被引：28

作者：

Inoue, M ^{[1
]}

Nakayamada, H ^{[1
]}

Tokuyama, S ^{[1
]}

Ueda, H ^{[1
]}

机构：

[1] NAGASAKI UNIV,SCH PHARMACEUT SCI,DEPT MOL PHARMACOL & NEUROSCI,NAGASAKI 852,JAPAN

来源：

NEUROSCIENCE LETTERS | 1997年 / 236卷 / 01期

关键词：

kyotorphin; bradykinin; Hoe140; leucine-arginine; pertussis toxin (PTX); peripheral analgesia; non-opioid; G protein;

D O I：

10.1016/S0304-3940(97)00760-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Bradykinin (BK) given into the plantar (i.pl.) of the mouse hind-limb produced a flexor response. The flexor responses were dependent on BK doses (0.02-20 pmol, i.pl.), and were completely abolished by Hoe140, a B-2-type BK receptor antagonist. Kyotorphin, an analgesic neuropeptide which shows enkephalin release in brain slices, produced a dose-dependent reduction of the BK-induced nociceptive responses in ranges of 10 pmol to 1 nmol (i.pl.). Such analgesic effects of kyotorphin were reversed by leucine-arginine, a specific kyotorphin receptor antagonist, but not by naloxone. The kyotorphin-analgesia was also abolished by pertussis toxin (PTX) pretreatment. These results suggest that peripheral analgesic effects of kyotorphin are mediated through mechanisms of kyotorphin specific receptor and PTX-sensitive G(i)/G(o), and that the enkephalin release is not necessary for this analgesia. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：60 / 62

页数：3

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